How can we guide families struggling with substance use? How can we help people support positive change in their loved ones? And how can we use science and kindness together to make a real impact on people’s lives? These are the considerations that informed the creation of the Invitation to Change Approach (ITC), a helping model developed and shared by the Foundation for Change. Built on the three pillars of Understanding, Awareness, and Action, the ITC first illuminates new perspectives on substance use and the process of change; next, creates a foundation of self-awareness to allow willingness to engage with emotional pain; and finally, emphasizes action by teaching behavioral reinforcement and communication skills. These concepts rest on science-backed principles and practices to support those in a change-facilitating role—and on a larger scale, they have the power to combat the pervasive stigmatizing cultural narratives about substance.